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Article

Consequences of cAMP and catalytic-subunit binding on the flexibility of the A-kinase regulatory subunit.

Biochemistry - 19 Dec 2000

Li F, Gangal M, Jones J M, Deich J, Lovett K E, Taylor S S, Johnson D A

Abstract excerpt

A combination of site-directed labeling and time-resolved fluorescence anisotropy was used to further elucidate the structure and underlying dynamic features of the type I regulatory (R(I)(alpha)) subunit of the cAMP-dependent protein kinase. Specifically, the consequences of cAMP and the catalytic (C)-subunit binding on the backbone flexibility around seven sites of cysteine substitution and fluorescein...

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Identifiers

PMID: 11112551
DOI: 10.1021/bi002196l

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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