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Article

Structure and topology of monomeric phospholamban in lipid membranes determined by a hybrid solution and solid-state NMR approach.

Proceedings of the National Academy of Sciences of the United States of America - 23 Jun 2009

Traaseth Nathaniel J, Shi Lei, Verardi Raffaello, Mullen Daniel G, Barany George, Veglia Gianluigi

Abstract excerpt

Phospholamban (PLN) is an essential regulator of cardiac muscle contractility. The homopentameric assembly of PLN is the reservoir for active monomers that, upon deoligomerization form 1:1 complexes with the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA), thus modulating the rate of calcium uptake. In lipid bilayers and micelles, monomeric PLN exists in equilibrium between a bent (or resting) T state and a...

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Source

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Identifiers

PMID: 19509339
DOI: 10.1073/pnas.0904290106
PMCID: PMC2700893

Genes

PLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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