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Article

Essential role for Pro21 in phospholamban for optimal inhibition of the Ca-ATPase.

Biochemistry - 13 Dec 2005

Li Jinhui, Boschek Curt B, Xiong Yijia, Sacksteder Colette A, Squier Thomas C, Bigelow Diana J

Abstract excerpt

We have investigated the functional role of the flexible hinge region centered near the sequence TIEMP(21), which connects the N-terminal cytosolic and C-terminal membrane-spanning helical domains of phospholamban (PLB). Specifically, we ask if the conformation of this region is important to attain optimal inhibitory interactions with the Ca-ATPase. A genetically engineered PLB mutant was constructed in which...

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Alanine
Amino Acid Sequence
Binding Sites
Calcium-Binding Proteins
Calcium-Transporting ATPases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Molecular

Protein Conformation

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PMID: 16331978
DOI: 10.1021/bi051075o

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