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Article

Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine-induced cell death.

The Journal of endocrinology - 11 Feb 2022

Karsai Maria, Zuellig Richard A, Lehmann Roger, Cuozzo Federica, Nasteska Daniela, Luca Edlira, Hantel Constanze, Hodson David J, Spinas Giatgen A, Rutter Guy A, Gerber Philipp A

Abstract excerpt

Pancreatic β-cells depend on the well-balanced regulation of cytosolic zinc concentrations, providing sufficient zinc ions for the processing and storage of insulin, but avoiding toxic effects. The zinc transporter ZnT8, encoded by SLC30A8,is a key player regarding islet cell zinc homeostasis, and polymorphisms in this gene are associated with altered type 2 diabetes susceptibility in man. The objective of this...

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Identifiers

PMID: 35017316
DOI: 10.1530/JOE-21-0271
PMCID: PMC8859919

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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