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Article

Transgenic copper/zinc superoxide dismutase modulates susceptibility to type I diabetes.

Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 1994

Kubisch H M, Wang J, Luche R, Carlson E, Bray T M, Epstein C J, Phillips J P

Abstract excerpt

A growing body of evidence suggests that active oxygen is an important participant in the destruction of the pancreatic beta cell, which, in turn, leads to type I or insulin-dependent diabetes mellitus. Consequently, genetic factors predisposing susceptibility to insulin-dependent diabetes mellitus may include those that determine active oxygen metabolism. A direct test of this hypothesis is provided by a...

Topics

Animals
Blood Glucose
Brain
Crosses, Genetic
Diabetes Mellitus, Experimental
Diabetes Mellitus, Type 1
Gene Expression
Genetic Predisposition to Disease
Heterozygote
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred Strains

Mice, Transgenic

Oxidative Stress

Pancreas

Polymerase Chain Reaction

RNA, Messenger

Superoxide Dismutase

Source

Open in PubMed Open full text

Identifiers

PMID: 7937925
DOI: 10.1073/pnas.91.21.9956
PMCID: PMC44936

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7937925-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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