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Article

Role of reactive oxygen species in injury-induced insulin resistance.

Molecular endocrinology (Baltimore, Md.) - 1 Mar 2011

Zhai Lidong, Ballinger Scott W, Messina Joseph L

Abstract excerpt

Acute insulin resistance is common after injury, infection, and critical illness. To investigate the role of reactive oxygen species (ROS) in critical illness diabetes, we measured hepatic ROS, which rapidly increased in mouse liver. Overexpression of superoxide dismutase 2, which decreased mitochondrial ROS levels, protected mice from the development of acute hepatic insulin resistance. Insulin-induced...

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Identifiers

PMID: 21239612
DOI: 10.1210/me.2010-0224
PMCID: PMC3045736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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