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Article

Tight association of the human Mel(1a)-melatonin receptor and G(i): precoupling and constitutive activity.

Molecular pharmacology - 1 Nov 1999

Roka F, Brydon L, Waldhoer M, Strosberg A D, Freissmuth M, Jockers R, Nanoff C

Abstract excerpt

If stably expressed in human embryonic kidney (HEK)293 cells, the human Mel(1a)-melatonin receptor activates G(i)-dependent, pertussis toxin-sensitive signaling pathways, i.e., inhibition of adenylyl cyclase and stimulation of phospholipase Cbeta; the latter on condition that G(q) is coactivated. The antagonist luzindole blocks the effects of melatonin and acts as an inverse agonist at the Mel(1a) receptor in...

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Identifiers

PMID: 10531408
DOI: 10.1124/mol.56.5.1014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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