Article
Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function.
Science signaling - 8 Oct 2013
Baba Kenkichi, Benleulmi-Chaachoua Abla, Journé Anne-Sophie, Kamal Maud, Guillaume Jean-Luc, Dussaud Sébastien, Gbahou Florence, Yettou Katia, Liu Cuimei, Contreras-Alcantara Susana, Jockers Ralf, Tosini Gianluca
Abstract excerpt
The formation of G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor (GPCR) heteromers enables signaling diversification and holds great promise for improved drug selectivity. Most studies of these oligomerization events have been conducted in heterologous expression systems, and in vivo validation is lacking in most cases, thus questioning the physiological significance of GPCR...
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