Article
The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization.
The EMBO journal - 12 Jul 2006
Levoye Angélique, Dam Julie, Ayoub Mohammed A, Guillaume Jean-Luc, Couturier Cyril, Delagrange Philippe, Jockers Ralf
Abstract excerpt
One-third of the approximately 400 nonodorant G protein-coupled receptors (GPCRs) are still orphans. Although a considerable number of these receptors are likely to transduce cellular signals in response to ligands that remain to be identified, they may also have ligand-independent functions. Several members of the GPCR family have been shown to modulate the function of other receptors through heterodimerization....
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