Article
Evaluation of mutant frequencies of chemically induced tumors and normal tissues in lambda/cII transgenic mice.
Environmental and molecular mutagenesis - 1 Jan 2005
Mirsalis Jon C, Shimon Julie A, Johnson Alphonso, Fairchild David, Kanazawa Nathan, Nguyen Tung, de Boer Johan, Glickman Barry, Winegar Richard A
Abstract excerpt
Genomic instability has been implicated as an important component in tumor progression. Evaluation of mutant frequencies (MFs) in tumors of transgenic mice containing nontranscribed marker genes should be useful for quantitating mutation rates in tumors as the physiologically inactive transgene provides neither a positive nor a negative selective pressure on the tumor. We have conducted long-term carcinogenicity...
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