Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expanded CD4+ and CD8+ T cell clones in elderly humans

1 May 1997

Abstract excerpt

The diversity of the human TCR repertoire in aging has been studied by examining the profiles of complementarity-determining region 3 (CDR3) sizes expressed by the BV families. The TCRBV CDR3 profile, which shows size heterogeneity in young adult humans, is significantly restricted in aged humans. Clonal T cell expansions were identified using a PCR-based approach, in one or more BV families from all 14 healthy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9127016
DOI: 10.4049/jimmunol.158.9.4493

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expanded CD4+ and CD8+ T cell clones in elderly humansPMID 9127016Read ↗

The blood of healthy individuals exhibits CD8 T cells with a highly altered TCR Vb repertoire but with an unmodified phenotype.Semantic proximity Read ↗

Age-related persistent clonal expansions of CD28(-) cells: phenotypic and molecular TCR analysis reveals both CD4(+) and CD4(+)CD8(+) cells with identical CDR3 sequences.Semantic proximity Read ↗

Effects of aging, cytomegalovirus infection, and EBV infection on human B cell repertoires.Semantic proximity Read ↗

Estimate of the total number of CD8+ clonal expansions in healthy adults using a new DNA heteroduplex-tracking assay for CDR3 repertoire analysis.Semantic proximity Read ↗

Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects.Semantic proximity Read ↗

Aging affects B‐cell antigen receptor repertoire diversity in primary and secondary lymphoid tissuesSemantic proximity Read ↗

Age-related decrease in TCR repertoire diversity measured with deep and normalized sequence profiling.Semantic proximity Read ↗

Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly.Semantic proximity Read ↗

Analysis of the heterogeneity of the BCR H-CDR3 repertoire in peripheral blood B cells of adult women with increasing age in Central ChinaSemantic proximity Read ↗

Large clonal expansions of human virus‐specific memory cytotoxic T lymphocytes within the CD57<sup>+</sup> CD28<sup>–</sup> CD8<sup>+</sup> T‐cell populationSemantic proximity Read ↗

Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire DiversitySemantic proximity Read ↗

Immunoglobulin VH gene expression in human aging.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.