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Article

Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes.

1 Apr 1992

Abstract excerpt

cDNA libraries for IgM heavy chain variable regions were prepared from unmanipulated peripheral blood lymphocytes of two healthy people. Partial sequencing of 103 clones revealed VH gene family use and complete CDR3 and JH sequences. The libraries differed in the two subjects. In one person's cDNA the VH5 family was overexpressed and the VH3 family underex- pressed relative to genomic complexity. In the second...

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Identifiers

PMID: 1556192
DOI: 10.1172/jci115719

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