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Chromosome 9p21 gene copy number and prognostic significance of p16 in ESFT

29 May 2007

Abstract excerpt

Chromosome 9p21 gene copy number in Ewing's sarcoma family of tumour (ESFT) cell lines and primary ESFT has been evaluated using Multiplex Ligation-dependent probe amplification, and the clinical significance of CDKN2A loss and p16/p14(ARF) expression investigated. Homozygous deletion of CDKN2A was identified in 4/9 (44%) of ESFT cell lines and 4/42 (10%) primary ESFT; loss of one copy of CDKN2A was identified in...

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PMID: 17533400
DOI: 10.1038/sj.bjc.6603819

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