Mutational alterations of the p16CDKN2A tumor suppressor gene have low incidence in mesenchymal chondrosarcoma.

doi:10.3727/000000001108747381

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Article

Mutational alterations of the p16CDKN2A tumor suppressor gene have low incidence in mesenchymal chondrosarcoma.

Oncology research - 1 Jan 2000

Bae D K, Park Y K, Chi S G, Lee C W, Unni K K

Abstract excerpt

Mutational inactivation of the cyclin-dependent kinase inhibitors (CDKIs) (p16INK4A/MTS1) tumor suppressor gene has been found in a variety of human tumor types. To investigate the involvement of CDKI abnormality in mesenchymal chondrosarcoma, alterations of CDKIs were examined in human mesenchymal chondrosarcoma tissues using a quantitative DNA/PCR, PCR-SSCP. Seven of 33 specimens (21.2%) showed abnormally low...

Topics

Base Sequence
Bone Neoplasms
Chondrosarcoma, Mesenchymal
Cyclin-Dependent Kinase Inhibitor p16
DNA Mutational Analysis
DNA Primers
Electrophoresis, Polyacrylamide Gel
Genes, p16
Humans
Leg
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational

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Open in PubMed

Identifiers

PMID: 11061340
DOI: 10.3727/000000001108747381

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