Article
Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors.
Oncogene - 1 Oct 1997
Kovar H, Jug G, Aryee D N, Zoubek A, Ambros P, Gruber B, Windhager R, Gadner H
Abstract excerpt
The pRB cell cycle regulatory cascade is frequently perturbed in neoplasia by overexpression of a component of the pRB-phosphorylating cyclin D1/CDK4 complex or by inactivation of pRB or the CDK4 inhibitors p16 and p15. We investigated the status and expression of p16, p15, CCND1, CDK4 and RB genes in the Ewing family of tumors. P16 loss was observed in 8 of 27 tumors (30%) and in 12 of 23 (52%) tumor cell lines...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.