Article
Among genes involved in the RB dependent cell cycle regulatory cascade, the p16 tumor suppressor gene is frequently lost in the Ewing family of tumors.
Oncogene - 1 Oct 1997
Kovar H, Jug G, Aryee D N, Zoubek A, Ambros P, Gruber B, Windhager R, Gadner H
Abstract excerpt
The pRB cell cycle regulatory cascade is frequently perturbed in neoplasia by overexpression of a component of the pRB-phosphorylating cyclin D1/CDK4 complex or by inactivation of pRB or the CDK4 inhibitors p16 and p15. We investigated the status and expression of p16, p15, CCND1, CDK4 and RB gen...
Topics
- Cell Cycle
- Cell Cycle Proteins
- Cyclin D1
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinases
- Gene Deletion
- Gene Expression
- Genes, p16
- Genes, p53
- Humans
- Mutation
- Prognosis
- Proto-Oncogene Proteins