Article
Low incidence of genetic alterations of the p16CDKN2a in clear cell chondrosarcoma.
International journal of oncology - 1 Oct 2001
Park Y K, Cho C H, Chi S G, Han C S, Ushigome S, Unni K K
Abstract excerpt
Mutational inactivation of the cyclin-dependent kinase inhibitors (CDKIs) (p16CDKN2a) tumor suppressor gene has been found in a variety of human tumor types. To investigate the involvement of CDKI abnormality in clear cell chondrosarcoma, alterations of CDKIs were examined in clear cell chondrosarcoma tissues using a quantitative DNA/PCR, PCR-SSCP. Two of 38 specimens (5.2%) we analyzed showed abnormally low...
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