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Article

Mutations in DNA replication genes reduce yeast life span.

Molecular and cellular biology - 1 Jun 2002

Hoopes Laura L Mays, Budd Martin, Choe Wonchae, Weitao Tao, Campbell Judith L

Abstract excerpt

Surprisingly, the contribution of defects in DNA replication to the determination of yeast life span has never been directly investigated. We show that a replicative yeast helicase/nuclease, encoded by DNA2 and a member of the same helicase subfamily as the RecQ helicases, is required for normal life span. All of the phenotypes of old wild-type cells, for example, extended cell cycle time, age-related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12024027
DOI: 10.1128/MCB.22.12.4136-4146.2002
PMCID: PMC133874

Genes

DNA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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