Article
A role for cryptochromes in sleep regulation.
BMC neuroscience - 20 Dec 2002
Wisor Jonathan P, O'Hara Bruce F, Terao Akira, Selby Chris P, Kilduff Thomas S, Sancar Aziz, Edgar Dale M, Franken Paul
Abstract excerpt
BACKGROUND: The cryptochrome 1 and 2 genes (cry1 and cry2) are necessary for the generation of circadian rhythms, as mice lacking both of these genes (cry1,2-/-) lack circadian rhythms. We studied sleep in cry1,2-/- mice under baseline conditions as well as under conditions of constant darkness and enforced wakefulness to determine whether cryptochromes influence sleep regulatory processes. RESULTS: Under all...
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