Article
Evidence for an interaction between adducin and Na(+)-K(+)-ATPase: relation to genetic hypertension.
The American journal of physiology - 1 Oct 1999
Ferrandi M, Salardi S, Tripodi G, Barassi P, Rivera R, Manunta P, Goldshleger R, Ferrari P, Bianchi G, Karlish S J
Abstract excerpt
Adducin point mutations are associated with genetic hypertension in Milan hypertensive strain (MHS) rats and in humans. In transfected cells, adducin affects actin cytoskeleton organization and increases the Na(+)-K(+)-pump rate. The present study has investigated whether rat and human adducin polymorphisms differently modulate rat renal Na(+)-K(+)-ATPase in vitro. We report the following. 1) Both rat and human...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.