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Article

alpha-Adducin mutations increase Na/K pump activity in renal cells by affecting constitutive endocytosis: implications for tubular Na reabsorption.

American journal of physiology. Renal physiology - 1 Aug 2008

Torielli Lucia, Tivodar Simona, Montella Rosa Chiara, Iacone Roberto, Padoani Gloria, Tarsini Paolo, Russo Ornella, Sarnataro Daniela, Strazzullo Pasquale, Ferrari Patrizia, Bianchi Giuseppe, Zurzolo Chiara

Abstract excerpt

Genetic variation in alpha-adducin cytoskeletal protein is implicated in the polymerization and bundling of actin and alteration of the Na/K pump, resulting in abnormal renal sodium transport and hypertension in Milan hypertensive rats and humans. To investigate the molecular involvement of alpha-adducin in controlling Na/K pump activity, wild-type or mutated rat and human alpha-adducin forms were, respectively,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18524856
DOI: 10.1152/ajprenal.90226.2008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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