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Article

PST 2238: A new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension.

The Journal of pharmacology and experimental therapeutics - 1 Mar 1999

Ferrari P, Ferrandi M, Tripodi G, Torielli L, Padoani G, Minotti E, Melloni P, Bianchi G

Abstract excerpt

A genetic alteration in the adducin genes is associated with hypertension and up-regulation of the expression of renal Na, K-ATPase in Milan-hypertensive (MHS) rats, in which increased ouabain-like factor (OLF) levels are also observed. PST 2238, a new antihypertensive compound that antagonizes the pressor effect of ouabain in vivo and normalizes ouabain-dependent up-regulation of the renal Na-K pump, was...

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PMID: 10027844

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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PST 2238: A new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension.PMID 10027844Read ↗

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