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Article

Hypertension-linked mutation of α-adducin increases CFTR surface expression and activity in HEK and cultured rat distal convoluted tubule cells.

PloS one - 1 Jan 2012

Mondini Anna, Sassone Francesca, Civello Davide Antonio, Garavaglia Maria Lisa, Bazzini Claudia, Rodighiero Simona, Vezzoli Valeria, Conti Fabio, Torielli Lucia, Capasso Giovanbattista, Paulmichl Markus, Meyer Giuliano

Abstract excerpt

The CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) activity and localization are influenced by the cytoskeleton, in particular by actin and its polymerization state. In this study we investigated whether the expression of the hypertensive mutations of α-adducin (G460W-S586C in humans, F316Y in rats), an actin capping protein, led to a functional modification of CFTR activity and surface expression....

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Source

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Identifiers

PMID: 23284854
DOI: 10.1371/journal.pone.0052014
PMCID: PMC3528715

Genes

CFTR
DCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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