Article
Pharmacogenomics and pharmacogenetics of hypertension: update and perspectives--the adducin paradigm.
Journal of the American Society of Nephrology : JASN - 1 Apr 2006
Manunta Paolo, Bianchi Giuseppe
Abstract excerpt
There is a growing literature on the potential prospective use of genome information to enhance success in finding new medicines. An example of a prospective efficacy of pharmacogenetic and pharmacogenomics is the detection and impact of adducin polymorphism on hypertension. Adducin is a heterodimeric cytoskeleton protein, the three subunits of which are encoded by genes (ADD1, ADD2, and ADD3) that map to three...
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