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Article

Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly.

Journal of virology - 1 Nov 1999

Baer G S, Ebert D H, Chung C J, Erickson A H, Dermody T S

Abstract excerpt

Persistent reovirus infections of murine L929 cells select cellular mutations that inhibit viral disassembly within the endocytic pathway. Mutant cells support reovirus growth when infection is initiated with infectious subvirion particles (ISVPs), which are intermediates in reovirus disassembly formed following proteolysis of viral outer-capsid proteins. However, mutant cells do not support growth of virions,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10516062
DOI: 10.1128/JVI.73.11.9532-9543.1999
PMCID: PMC112988

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Source receipt: pubmed, retrieved 7 Sept 2026.

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