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Article

Reovirus variants selected for resistance to ammonium chloride have mutations in viral outer-capsid protein sigma3.

Journal of virology - 1 Jan 2006

Clark Kimberly M, Wetzel J Denise, Gu Yingqi, Ebert Daniel H, McAbee Stephanie A, Stoneman Emily K, Baer Geoffrey S, Zhu Yuwei, Wilson Gregory J, Prasad B V V, Dermody Terence S

Abstract excerpt

Mammalian reoviruses are internalized into cells by receptor-mediated endocytosis. Within the endocytic compartment, the viral outer capsid undergoes acid-dependent proteolysis resulting in removal of the sigma3 protein and proteolytic cleavage of the mu1/mu1C protein. Ammonium chloride (AC) is a weak base that blocks disassembly of reovirus virions by inhibiting acidification of intracellular vacuoles. To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16378970
DOI: 10.1128/JVI.80.2.671-681.2006
PMCID: PMC1346852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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