Article

Breast tumor-associated metalloproteases restrict reovirus oncolysis by cleaving the σ1 cell-attachment protein, and can be overcome by mutation of σ1

2019-08-25

Abstract excerpt

<h4>ABSTRACT</h4> Reovirus is undergoing clinical testing as an oncolytic therapy for breast cancer. Given that reovirus naturally evolved to thrive in enteric environments, we sought to better understand how breast tumor microenvironments impinge on reovirus infection. Reovirus was treated with extracellular extracts generated from polyoma virus middle T-antigen-derived mouse breast tumors. Unexpectedly, these...

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Literature Corpus work: 66f9a7d3-baaa-546a-9a3e-0c637fdecbca
DOI: 10.1101/742478

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