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Article

Adaptation of reovirus to growth in the presence of protease inhibitor E64 segregates with a mutation in the carboxy terminus of viral outer-capsid protein sigma3.

Journal of virology - 1 Apr 2001

Ebert D H, Wetzel J D, Brumbaugh D E, Chance S R, Stobie L E, Baer G S, Dermody T S

Abstract excerpt

Reovirus virions are internalized into cells by receptor-mediated endocytosis. Within the endocytic compartment, the viral outer capsid undergoes acid-dependent proteolysis leading to degradation of sigma3 protein and proteolytic cleavage of micro1/micro1C protein. E64 is a specific inhibitor of cysteine-containing proteases that blocks disassembly of reovirus virions. To identify domains in reovirus proteins...

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Identifiers

PMID: 11238846
DOI: 10.1128/JVI.75.7.3197-3206.2001
PMCID: PMC114113

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