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Article

Masking epilepsy by combining two epilepsy genes.

Nature neuroscience - 1 Dec 2007

Glasscock Edward, Qian Jing, Yoo Jong W, Noebels Jeffrey L

Abstract excerpt

Inherited errors in ion channel genes comprise the largest subset of monogenic causes of idiopathic epilepsy, and pathogenic variants contribute to genetic risk in the complex inheritance of this common disorder. We generated a digenic mouse model of human idiopathic epilepsy by combining two epilepsy-associated ion channel mutations with mutually opposing excitability defects and overlapping subcellular...

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PMID: 17982453
DOI: 10.1038/nn1999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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