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Article

Two novel alleles of tottering with distinct Ca(v)2.1 calcium channel neuropathologies.

Neuroscience - 31 Jul 2008

Miki T, Zwingman T A, Wakamori M, Lutz C M, Cook S A, Hosford D A, Herrup K, Fletcher C F, Mori Y, Frankel W N, Letts V A

Abstract excerpt

The calcium channel CACNA1A gene encodes the pore-forming, voltage-sensitive subunit of the voltage-dependent calcium Ca(v)2.1 type channel. Mutations in this gene have been linked to several human disorders, including familial hemiplegic migraine, episodic ataxia 2 and spinocerebellar ataxia type 6. The mouse homologue, Cacna1a, is associated with the tottering, Cacna1a(tg), mutant series. Here we describe two...

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Identifiers

PMID: 18597946
DOI: 10.1016/j.neuroscience.2008.05.028
PMCID: PMC2633778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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