Article
A targeted mutation in Cacng4 exacerbates spike-wave seizures in stargazer (Cacng2) mice.
Proceedings of the National Academy of Sciences of the United States of America - 8 Feb 2005
Letts Verity A, Mahaffey Connie L, Beyer Barbara, Frankel Wayne N
Abstract excerpt
The voltage-dependent calcium channel gamma4 subunit protein, CACNG4, is closely related to the gamma2 subunit, CACNG2. Both are expressed primarily in the brain and share 53% amino acid identity. The Cacng2 gene is disrupted in the stargazer mouse, with its distinctive phenotype including ataxia, frequent absence seizure episodes, and head elevation. A disruption within Cacng4 was engineered to assess its...
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