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Article

The Schizosaccharomyces pombe hst4(+) gene is a SIR2 homologue with silencing and centromeric functions.

Molecular biology of the cell - 1 Oct 1999

Freeman-Cook L L, Sherman J M, Brachmann C B, Allshire R C, Boeke J D, Pillus L

Abstract excerpt

Although silencing is a significant form of transcriptional regulation, the functional and mechanistic limits of its conservation have not yet been established. We have identified the Schizosaccharomyces pombe hst4(+) gene as a member of the SIR2/HST silencing gene family that is defined in organisms ranging from bacteria to humans. hst4Delta mutants grow more slowly than wild-type cells and have abnormal...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10512858
DOI: 10.1091/mbc.10.10.3171
PMCID: PMC25575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Schizosaccharomyces pombe hst4(+) gene is a SIR2 homologue with silencing and centromeric functions.PMID 10512858Read ↗

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