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Article

Population distribution and effects on drug metabolism of a genetic variant in the 5' promoter region of CYP3A4.

Clinical pharmacology and therapeutics - 1 Sept 1999

Ball S E, Scatina J, Kao J, Ferron G M, Fruncillo R, Mayer P, Weinryb I, Guida M, Hopkins P J, Warner N, Hall J

Abstract excerpt

BACKGROUND: There are large interindividual differences in CYP3A4 expression and in the metabolism of drug substrates for this enzyme. We and others have identified a polymorphism in the 5' promotor region of the CYP3A4 gene; however, its functional significance is not currently known. This study was conducted to determine whether this polymorphism plays a clinically important role in determining CYP3A4...

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Identifiers

PMID: 10511065
DOI: 10.1016/S0009-9236(99)70037-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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