Article
CYP3A activity in African American and European American men: population differences and functional effect of the CYP3A4*1B5'-promoter region polymorphism.
Clinical pharmacology and therapeutics - 1 Jul 2000
Wandel C, Witte J S, Hall J M, Stein C M, Wood A J, Wilkinson G R
Abstract excerpt
OBJECTIVE: Cytochrome P4503A (CYP3A) activity exhibits considerable interindividual variability. Possible differences in CYP3A activity were investigated in European American and African American men with the use of midazolam as an in vivo probe. METHODS: Midazolam was simultaneously administered intravenously (1 mg, [15N3]-labeled) and orally (2 mg, unlabeled in capsule form) to 15 young healthy European...
Topics
- Administration, Oral
- Adult
- Aged
- Area Under Curve
- Aryl Hydrocarbon Hydroxylases
- Biological Availability
- Black People
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System
- GABA Modulators