Article
A new CYP3A5 variant, CYP3A5*11, is shown to be defective in nifedipine metabolism in a recombinant cDNA expression system.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2007
Lee Su-Jun, van der Heiden Ilse P, Goldstein Joyce A, van Schaik Ron H N
Abstract excerpt
A new CYP3A5 variant, CYP3A5*11, was found in a white European subject by DNA sequencing. The CYP3A5*11 allele contains a single nucleotide polymorphism (SNP) (g.3775A>G) in exon 2, which results in a Tyr53Cys substitution, and a g.6986A>G splice change, the latter SNP previously reported in the...
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