Article
Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: pathological correlations.
British journal of cancer - 1 Oct 1999
Gonzalez R, Silva J M, Dominguez G, Garcia J M, Martinez G, Vargas J, Provencio M, España P, Bonilla F
Abstract excerpt
Loss of heterozygosity (LOH) in loci of the 15q15.1, 12p13, 1p32, 17q21 and 13q12-13 regions may collaborate in the inactivation of RAD51, RAD52, RAD54, BRCA1, BRCA2 and possibly other genes implicated in the repair of double-stranded DNA and in DNA recombination. We investigate allelic losses in microsatellites of the RAD51, RAD52, RAD54, BRCA1 and BRCA2 regions, and their correlations with nine pathologic...
Topics
- Age Factors
- Aged
- BRCA1 Protein
- BRCA2 Protein
- Biomarkers, Tumor
- Breast Neoplasms
- Carcinoma
- Chromosomes, Human
- DNA Helicases
- DNA Repair
- DNA Repair Enzymes
- DNA-Binding Proteins
- Female
- Fungal Proteins