Article
Loss of heterozygosity in human breast carcinomas in the ataxia telangiectasia, Cowden disease and BRCA1 gene regions.
Oncogene - 23 Jan 1997
Kerangueven F, Eisinger F, Noguchi T, Allione F, Wargniez V, Eng C, Padberg G, Theillet C, Jacquemier J, Longy M, Sobol H, Birnbaum D
Abstract excerpt
To appreciate the involvement of known or potential susceptibility genes in sporadic breast tumors, we have searched for chromosomal deletions by studying loss of heterozygosity (LOH) at 43 microsatellite (CA)n markers from human chromosomes 10, 11 and 17, in 115 unselected consecutive samples of...
Topics
- Alleles
- Ataxia Telangiectasia
- Breast Neoplasms
- Chromosome Deletion
- Chromosomes, Human, Pair 10
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 17
- Disease Susceptibility
- Female
- Genes, BRCA1
- Genetic Markers
- Hamartoma Syndrome, Multiple
- Humans
- Microsatellite Repeats