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Epistasis within the MHC contributes to the genetic architecture of celiac disease

2014-02-07

Abstract excerpt

Epistasis has long been thought to contribute to the genetic aetiology of complex diseases, yet few robust epistatic interactions in humans have been detected. We have conducted exhaustive genome-wide scans for pairwise epistasis in five independent celiac disease (CD) case-control studies, using a rapid model-free approach to examine over 500 billion SNP pairs in total. We found 20 significant epistatic signals w...

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Literature Corpus work
e9c6c2a3-6283-5553-9e24-2595ed276181
DOI
10.1101/002485
Open publication

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Epistasis within the MHC contributes to the genetic architecture of celiac diseaseDOI 10.1101/002485
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