Article
A gene telomeric of the HLA class I region is involved in predisposition to both type 1 diabetes and coeliac disease.
Tissue antigens - 1 Aug 1999
Lie B A, Sollid L M, Ascher H, Ek J, Akselsen H E, Rønningen K S, Thorsby E, Undlien D E
Abstract excerpt
We have recently shown that an as yet unidentified gene within or in the vicinity of the HLA complex, in linkage disequilibrium with microsatellite D6S2223, modifies the risk to develop type 1 diabetes independently of HLA-DR and -DQ genes. This microsatellite is located 2.5 Mb telomeric to HLA-F and particular alleles at this microsatellite modifies the risk encoded by the high-risk DRB1*03-DQA1*0501-DQB1*0201...
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