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Article

Colorectal cancer with and without microsatellite instability involves different genes

1 Nov 1999

Abstract excerpt

There is evidence supporting a multistep genetic model for colorectal tumorigenesis. In familial adenomatosis polyposis (FAP), the inherited defect is a mutation in the APC gene. The vast majority of all sporadic colorectal cancers also show mutations in the APC gene, and the tumorigenesis in sporadic colorectal cancer and FAP is assumed to involve the same genes. Hereditary nonpolyposis colorectal cancer (HNPCC)...

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Identifiers

PMID: 10502323
DOI: 10.1002/(sici)1098-2264(199911)26:3<247::aid-gcc9>3.0.co;2-h

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