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Article

Alteration of pRb/p16/cdk4 regulation in human osteosarcoma

22 Oct 1999

Abstract excerpt

Cell-cycle regulation depends on a fine balance between cyclin-cyclin-dependent kinase complexes and a family of kinase inhibitors that bind cyclin-cdk complexes and block their activity. To investigate the role of mechanisms regulating cell-cycle progression in human osteosarcomas (OS), pRb/p16/cdk4 expression was analyzed in 39 high-grade OS; 19 of these developed metastasis during follow-up. Positive reaction...

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PMID: 10502725
DOI: 10.1002/(sici)1097-0215(19991022)84:5<489::aid-ijc7>3.0.co;2-d

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