Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The prognostic significance and value of cyclin D1, CDK4 and p16 in human breast cancer

21 Jan 2013

Abstract excerpt

INTRODUCTION: Loss of the retinoblastoma protein tumor suppressor gene (RB) coding for a nuclear phosphoprotein that regulates the cell cycle is found in many human cancers and probably leads to disruption of the p16-cyclin D1-CDK4/6-RB pathway. Cyclin D1 is known to activate CDK4, which then phosphorylates the RB protein, leading to cell cycle progression. p16 inhibits CDK4, keeping RB hypophosphorylated and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced Breast Cancer Therapies
Share to Cancer, Lipids, and Metabolism
Share to Cancer-related Molecular Pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23336272
DOI: 10.1186/bcr3376

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The prognostic significance and value of cyclin D1, CDK4 and p16 in human breast cancerPMID 23336272Read ↗

An update on the implications of cyclin D1 in oral carcinogenesisSemantic proximity Read ↗

Abnormal expression of cell cycle regulatory proteins in ductal and lobular carcinomas of the breast.Semantic proximity Read ↗

Prognostic significance of cyclin D1 protein expression and gene amplification in invasive breast carcinomaSemantic proximity Read ↗

Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer.Semantic proximity Read ↗

Cyclin D1 protein expression and function in human breast cancerSemantic proximity Read ↗

Cyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcomeSemantic proximity Read ↗

p16INK4A Positively Regulates Cyclin D1 and E2F1 through Negative Control of AUF1Semantic proximity Read ↗

The Clinicopathological Significance of the Cyclin D1/E1–Cyclin-Dependent Kinase (CDK2/4/6)–Retinoblastoma (RB1/pRB1) Pathway in Epithelial Ovarian CancersSemantic proximity Read ↗

Abnormal Expression of p16<sup>INK4a</sup>, Cyclin D1, Cyclin‐Dependent Kinase 4 and Retinoblastoma Protein in Gastric CarcinomasSemantic proximity Read ↗

Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: biological and clinical implications.Semantic proximity Read ↗

Cyclin D1 Amplification and p16(MTS1/CDK4I) Deletion Correlate With Poor Prognosis in Head and Neck TumorsSemantic proximity Read ↗

Cyclin D1 protein overexpression and CCND1 amplification in breast carcinomas: an immunohistochemical and chromogenic in situ hybridisation analysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.