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Article

Delay in serum stimulation of Erk activity caused by oncogenic transformation.

Oncogene - 18 Apr 1996

Greulich H, Reichman C, Hanafusa H

Abstract excerpt

Mitogenic growth factor stimulation activates several signal transduction pathways, including the well-characterized Ras-Erk pathway, resulting in transient activation of Erk1 and Erk2. Oncogenic transformation, however, causes constitutive activation of growth signalling pathways, resulting in an accelerated rate of cell division. We investigated the effects of transformation on serum and growth factor...

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PMID: 8622889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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