Article
Delay in serum stimulation of Erk activity caused by oncogenic transformation.
Oncogene - 18 Apr 1996
Greulich H, Reichman C, Hanafusa H
Abstract excerpt
Mitogenic growth factor stimulation activates several signal transduction pathways, including the well-characterized Ras-Erk pathway, resulting in transient activation of Erk1 and Erk2. Oncogenic transformation, however, causes constitutive activation of growth signalling pathways, resulting in a...
Topics
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Cycle Proteins
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Chick Embryo
- Culture Media, Serum-Free
- Dual Specificity Phosphatase 1
- Enzyme Activation
- ErbB Receptors
- Fibroblasts
- Genes, ras
- Immediate-Early Proteins
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinase 3
- Mitogen-Activated Protein Kinase Kinases
- Mitogen-Activated Protein Kinases
- Mutation