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Article

Constitutively active mitogen-activated protein kinase kinase 1 (MAPKK1) and MAPKK2 mediate similar transcriptional and morphological responses.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Feb 1996

Mansour S J, Candia J M, Gloor K K, Ahn N G

Abstract excerpt

Both mitogen-activated protein kinase kinase 1 (MAPKK1) and MAPKK2 function downstream of the proto-oncogene product Raf in signaling pathways that affect cell proliferation and differentiation. The isoforms were previously shown to be differentially regulated in two significant ways: (a) MAPKK1,...

Topics

3T3 Cells
Adaptor Protein Complex 1
Adaptor Protein Complex alpha Subunits
Adaptor Proteins, Vesicular Transport
Amino Acid Sequence
Animals
Isoenzymes
Membrane Proteins
Mice
Mitogen-Activated Protein Kinase Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Oncogene Proteins v-mos

Phenotype

Protein Kinases

Recombinant Proteins

Transcription, Genetic

Transformation, Genetic

Source

Identifiers

PMID: 8822208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8822208-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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