Article
ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially.
Journal of biology - 1 Jan 2006
Vantaggiato Chiara, Formentini Ivan, Bondanza Attilio, Bonini Chiara, Naldini Luigi, Brambilla Riccardo
Abstract excerpt
BACKGROUND: The mitogen-activated protein (MAP) kinases p44ERK1 and p42ERK2 are crucial components of the regulatory machinery underlying normal and malignant cell proliferation. A currently accepted model maintains that ERK1 and ERK2 are regulated similarly and contribute to intracellular signaling by phosphorylating a largely common subset of substrates, both in the cytosol and in the nucleus. RESULTS: Here, we...
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