Article
Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis.
Gastroenterology - 1 Oct 1999
Tountas N A, Casini-Raggi V, Yang H, Di Giovine F S, Vecchi M, Kam L, Melani L, Pizarro T T, Rotter J I, Cominelli F
Abstract excerpt
BACKGROUND & AIMS: The role of the interleukin (IL)-1 receptor antagonist (IL-1ra) in predisposing an individual to inflammatory bowel disease (IBD) is controversial. This study aimed to determine the association between intron 2 IL-1ra polymorphism and IBD by performing a multiethnic case-control study and to assess its functional significance. METHODS: A total of 236 patients with ulcerative colitis (UC), 196...
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