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Article

Evidence of genetic heterogeneity in IBD: 1. The interleukin-1 receptor antagonist in the predisposition to suffer from ulcerative colitis.

European journal of gastroenterology & hepatology - 1 Feb 1996

Bioque G, Bouma G, Crusius J B, Koutroubakis I, Kostense P J, Meuwissen S G, Peña A S

Abstract excerpt

OBJECTIVE: To investigate a polymorphism within intron 2 of the interleukin-1 receptor antagonist (IL-1ra) gene in a Dutch white population of patients with ulcerative colitis and Crohn's disease. DESIGN: Genotype and allele frequencies of the polymorphic region in the IL-1ra gene were determined in 111 unrelated patients with ulcerative colitis, 92 patients with Crohn's disease, and 86 healthy controls. METHODS:...

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PMID: 8723412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence of genetic heterogeneity in IBD: 1. The interleukin-1 receptor antagonist in the predisposition to suffer from ulcerative colitis.PMID 8723412Read ↗

Genetic heterogeneity within ulcerative colitis determined by an interleukin-1 receptor antagonist gene polymorphism and antineutrophil cytoplasmic antibodies.Semantic proximity Read ↗

Association of the interleukin 1 receptor antagonist gene with ulcerative colitis in Northern European Caucasians.Semantic proximity Read ↗

Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis.Semantic proximity Read ↗

Significant differences in the interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in a Hungarian population with inflammatory bowel disease.Semantic proximity Read ↗

Significance of interleukin-1beta and interleukin-1 receptor antagonist genetic polymorphism in inflammatory bowel diseases.Semantic proximity Read ↗

Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist.Semantic proximity Read ↗

Allelic polymorphism in IL-1 beta and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel disease.Semantic proximity Read ↗

Lack of association between an interleukin-1 receptor antagonist gene polymorphism and ulcerative colitis.Semantic proximity Read ↗

IL-1 receptor antagonist (IL-1Ra) gene polymorphism in patients with inflammatory bowel disease in India.Semantic proximity Read ↗

Cytokine gene polymorphisms in inflammatory bowel disease.Semantic proximity Read ↗

Absence of a genetic association between IL-1RN and IL-1B gene polymorphisms in ulcerative colitis and Crohn disease in multiple populations from northeast England.Semantic proximity Read ↗

Imbalance of the interleukin 1 system in colonic mucosa--association with intestinal inflammation and interleukin 1 receptor antagonist [corrected] genotype 2.Semantic proximity Read ↗

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