Article
Allelic polymorphism in IL-1 beta and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel disease.
Clinical and experimental immunology - 1 Nov 1995
Bioque G, Crusius J B, Koutroubakis I, Bouma G, Kostense P J, Meuwissen S G, Peña A S
Abstract excerpt
Recent reports have shown that allele 2 of the IL-1 receptor antagonist (IL-1Ra) gene is over-represented in ulcerative colitis (UC). Healthy individuals carrying allele 2 of this gene have increased production of IL-1Ra protein. Since the final outcome of the biological effects of IL-1 beta may depend on the relative proportion of these two cytokines, we have studied if a TaqI polymorphism in the IL-1 beta gene,...
Topics
- Alleles
- Base Sequence
- Colitis, Ulcerative
- Crohn Disease
- DNA Primers
- Gene Frequency
- Humans
- Interleukin 1 Receptor Antagonist Protein
- Interleukin-1
- Molecular Sequence Data
- Sialoglycoproteins