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Article

Allelic polymorphism in IL-1 beta and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel disease.

Clinical and experimental immunology - 1 Nov 1995

Bioque G, Crusius J B, Koutroubakis I, Bouma G, Kostense P J, Meuwissen S G, Peña A S

Abstract excerpt

Recent reports have shown that allele 2 of the IL-1 receptor antagonist (IL-1Ra) gene is over-represented in ulcerative colitis (UC). Healthy individuals carrying allele 2 of this gene have increased production of IL-1Ra protein. Since the final outcome of the biological effects of IL-1 beta may depend on the relative proportion of these two cytokines, we have studied if a TaqI polymorphism in the IL-1 beta gene,...

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Identifiers

PMID: 7586694
DOI: 10.1111/j.1365-2249.1995.tb03793.x
PMCID: PMC1553429

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Source receipt: pubmed, retrieved 7 Sept 2026.

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