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Article

Dosage requirement of Pitx2 for development of multiple organs.

Development (Cambridge, England) - 1 Oct 1999

Gage P J, Suh H, Camper S A

Abstract excerpt

Pitx2 is a homeodomain transcription factor that is mutated in Rieger syndrome, a haploinsufficiency disorder affecting eyes and teeth. Pitx2 also has a postulated role in left-right axis determination. We assessed the requirements for Pitx2 directly by generating hypomorphic and null alleles. He...

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Share to Eye Abnormalities
Share to Fetal Heart
Share to Genes, Homeobox

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Defects, Congenital

Share to Homeobox Protein PITX2

Share to Paired Box Transcription Factors

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Source

Identifiers

PMID: 10498698
DOI: 10.1242/dev.126.20.4643

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10498698-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Dosage requirement of Pitx2 for development of multiple organs.PMID 10498698Read ↗

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