Article
Regulation of left-right asymmetry by thresholds of Pitx2c activity.
Development (Cambridge, England) - 1 Jun 2001
Liu C, Liu W, Lu M F, Brown N A, Martin J F
Abstract excerpt
Although much progress has been made in understanding the molecular mechanisms regulating left-right asymmetry, the final events of asymmetric organ morphogenesis remain poorly understood. The phenotypes of human heterotaxia syndromes, in which organ morphogenesis is uncoupled, have suggested that the early and late events of left-right asymmetry are separable. The Pitx2 homeobox gene plays an important role in...
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