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Article

The hepatitis C virus internal ribosome entry site adopts an ion-dependent tertiary fold.

Journal of molecular biology - 24 Sept 1999

Kieft J S, Zhou K, Jubin R, Murray M G, Lau J Y, Doudna J A

Abstract excerpt

Hepatitis C virus (HCV) contains an internal ribosome entry site (IRES) located in the 5' untranslated region of the genomic RNA that drives cap-independent initiation of translation of the viral message. The approximate secondary structure and minimum functional length of the HCV IRES are known, and extensive mutagenesis has established that nearly all secondary structural domains are critical for activity....

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Identifiers

PMID: 10497018
DOI: 10.1006/jmbi.1999.3095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The hepatitis C virus internal ribosome entry site adopts an ion-dependent tertiary fold.PMID 10497018Read ↗

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HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation.Semantic proximity Read ↗

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